1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → HCID 70202722, compound

HRID 342572Notes

Reaction equation

HRID 342572 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[CH2:19]([N:26]1[CH:31]=[C:30]([C:32]#[N:33])[C:29](=[O:34])[N:28]([CH2:35][CH2:36][CH2:37][Cl:38])[C:27]1=[O:39])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[ClH:38].[CH2:19]([N:26]1[CH:31]=[C:30]([C:32]#[N:33])[C:29](=[O:34])[N:28]([CH2:35][CH2:36][CH2:37][N:14]2[CH2:15][CH2:16][N:11]([C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[O:4][CH2:3][C:2]([F:1])([F:17])[F:18])[CH2:12][CH2:13]2)[C:27]1=[O:39])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 104915651-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazineHCID 54210499HCID 54210499, compound

Product 1

HCID 70202722HCID 70202722, compound

Procedure

substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 1-benzyl-3-(3-chloropropyl)-5-cyano-2,4(1H,3H)-pyrimidinedione gave 1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-cyano-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 142°-143° C.; Anal.: Calcd. for C27H28F3N5O3.(HCl)1.2.(H2O)0.5 : C, 57.50; H, 5.18; N, 12.42%; Found: C, 55.93; H, 5.22; N, 11.94%;

Sources & evidence

ORD record
ord-4259c1b6dfe24556bb464db5747a448b
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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