1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → HCID 70202722, compound

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Reaction Steps

substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 1-benzyl-3-(3-chloropropyl)-5-cyano-2,4(1H,3H)-pyrimidinedione gave 1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-cyano-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 142°-143° C.; Anal.: Calcd. for C27H28F3N5O3.(HCl)1.2.(H2O)0.5 : C, 57.50; H, 5.18; N, 12.42%; Found: C, 55.93; H, 5.22; N, 11.94%;

Provenance & Evidence