1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → HCID 70200995, compound

HRID 342573Notes

Reaction equation

HRID 342573 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[Cl:19][CH2:20][CH2:21][CH2:22][N:23]1[C:28](=[O:29])[C:27]([CH3:30])=[CH:26][N:25]([CH2:31][C:32]2[O:33][CH:34]=[CH:35][CH:36]=2)[C:24]1=[O:37]>>[ClH:19].[F:18][C:2]([F:1])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][N:14]([CH2:20][CH2:21][CH2:22][N:23]2[C:28](=[O:29])[C:27]([CH3:30])=[CH:26][N:25]([CH2:31][C:32]3[O:33][CH:34]=[CH:35][CH:36]=3)[C:24]2=[O:37])[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 104915651-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazineHCID 54554978HCID 54554978, compound

Product 1

HCID 70200995HCID 70200995, compound

Procedure

substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 3-(3-chloropropyl)-1-fur-2-ylmethyl-5-methyl-2,4(1H,3H)-pyrimidinedione gave 3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine-1-yl}propyl)-1-fur-2-ylmethyl-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 132°-134° C.; Anal.: Calcd. for C25H29F3N4O4.(HCl)2 : C, 51.81; H, 5.39; N, 9.66%; Found: C, 51.89; H, 5.44; N, 9.55%;

Sources & evidence

ORD record
ord-1a5d98ba57b84a089e9d8a0870a2e864
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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