1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → HCID 70201952, compound

HRID 342575Notes

Reaction equation

HRID 342575 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[Cl:19][CH2:20][CH2:21][CH2:22][N:23]1[C:28](=[O:29])[C:27]([CH3:30])=[CH:26][N:25]([CH3:31])[C:24]1=[O:32]>>[ClH:19].[F:18][C:2]([F:1])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][N:14]([CH2:20][CH2:21][CH2:22][N:23]2[C:28](=[O:29])[C:27]([CH3:30])=[CH:26][N:25]([CH3:31])[C:24]2=[O:32])[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 104915651-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazineHCID 54089505HCID 54089505, compound

Product 1

HCID 70201952HCID 70201952, compound

Procedure

substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 3-(3-chloropropyl)-1,5-dimethyl-2,4(1H,3H)-pyrimidinedione gave 3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-1,5-dimethyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 212°14 213° C.; Anal.: Calcd. for C21H27F3N4O3.(HCl)2 : C, 49.12; H, 5.69; N, 10.91%; Found: C, 48.97; H, 5.68; N, 10.77%;

Sources & evidence

ORD record
ord-3d749494f3dc45408c4332f686df82d0
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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