1-(3-chloropropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione → 1-{3-[4-(4-chloro-2-methoxyphenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

HRID 342578Notes

Reaction equation

HRID 342578 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[C:4]([O:14][CH3:15])[CH:3]=1.Cl[CH2:17][CH2:18][CH2:19][N:20]1[CH:25]=[C:24]([CH3:26])[C:23](=[O:27])[NH:22][C:21]1=[O:28]>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:9][CH2:10][N:11]([CH2:17][CH2:18][CH2:19][N:20]3[CH:25]=[C:24]([CH3:26])[C:23](=[O:27])[NH:22][C:21]3=[O:28])[CH2:12][CH2:13]2)=[C:4]([O:14][CH3:15])[CH:3]=1

Participants

3

Reactant 2

HCID 120913751-(3-chloropropyl)-5-methyl-2,4(1H,3H)-pyrimidinedioneHCID 158406631-(4-Chloro-2-methoxyphenyl)piperazine

Product 1

HCID 702012991-{3-[4-(4-chloro-2-methoxyphenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

Procedure

substituting 1-(4-chloro-2-methoxyphenyl)piperazine and 1-(3-chloropropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione gave 1-{3-[4-(4-chloro-2-methoxyphenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 154°-155° C.; Anal.: Calcd. for C19H25ClN4O3.(HCl)2 : C, 44.05; H, 6.37; N, 10.81%; Found: C, 44.26; H, 6.08; N, 10.46%;

Sources & evidence

ORD record
ord-72fd971ca9c34fd49b1805a02d7a1f09
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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