HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-chloropropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione → 3-(3-{4-[4-hydroxy-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-chloropropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione | HCID 11041835 | — |
| Reactant | 1-[4-Hydroxy-2-(2,2,2-trifluoroethoxy)phenyl]piperazine | HCID 70201004 | — |
| Product | 3-(3-{4-[4-hydroxy-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride | HCID 70198236 | — |
Reaction Steps
substituting 1-[4-hydroxy-2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 3-(3-chloropropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione gave 3-(3-{4-[4-hydroxy-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 232°-242° C.; Anal.: Calcd. for C20H25F3N4O4.HCl: C, 49.63; H, 5.59; N, 11.02%; Found: C, 49.62; H, 5.65; N, 10.66%;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05859014 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-6a784db1e3df43ec8283ebb369dfc7fb |
| Source note | uspto-grants-1999_01 |