1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → 3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

HRID 342580Notes

Reaction equation

HRID 342580 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[Cl:19][CH2:20][CH2:21][CH2:22][N:23]1[C:28](=[O:29])[CH:27]=[C:26]([CH3:30])[NH:25][C:24]1=[O:31]>>[ClH:19].[F:18][C:2]([F:1])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][N:14]([CH2:20][CH2:21][CH2:22][N:23]2[C:28](=[O:29])[CH:27]=[C:26]([CH3:30])[NH:25][C:24]2=[O:31])[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 104915651-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazineHCID 540590213-(3-chloropropyl)-6-methyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 702016173-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

Procedure

substituting 1-[2-(2,2,2-trifluoroethoxy)pheny]piperazine and 3-(3-chloropropyl)-6-methyl-2,4(1H,3H)-pyrimidinedione gave 3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 218°-220° C.; Anal.: Calcd. for C20H25F3N4O3.(HCl)2 : C, 48.10; H, 5.44; N, 11.22%; Found: C, 47.85; H, 5.48; N, 11.08%;

Sources & evidence

ORD record
ord-e06b439a04fa4488b182659a9078b92f
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

Loading…