HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → 3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine | HCID 10491565 | — |
| Reactant | 3-(3-chloropropyl)-6-methyl-2,4(1H,3H)-pyrimidinedione | HCID 54059021 | — |
| Product | 3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride | HCID 70201617 | — |
Reaction Steps
substituting 1-[2-(2,2,2-trifluoroethoxy)pheny]piperazine and 3-(3-chloropropyl)-6-methyl-2,4(1H,3H)-pyrimidinedione gave 3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 218°-220° C.; Anal.: Calcd. for C20H25F3N4O3.(HCl)2 : C, 48.10; H, 5.44; N, 11.22%; Found: C, 47.85; H, 5.48; N, 11.08%;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05859014 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-e06b439a04fa4488b182659a9078b92f |
| Source note | uspto-grants-1999_01 |