1-(4-Fluoro-2-methoxyphenyl)piperazine → 3-{3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propyl}-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

HRID 342583Notes

Reaction equation

HRID 342583 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[C:4]([O:14][CH3:15])[CH:3]=1.[Cl:16][CH2:17][CH2:18][CH2:19][N:20]1[C:25](=[O:26])[CH:24]=[C:23]([CH3:27])[NH:22][C:21]1=[O:28]>>[ClH:16].[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:9][CH2:10][N:11]([CH2:17][CH2:18][CH2:19][N:20]3[C:25](=[O:26])[CH:24]=[C:23]([CH3:27])[NH:22][C:21]3=[O:28])[CH2:12][CH2:13]2)=[C:4]([O:14][CH3:15])[CH:3]=1

Participants

3

Reactant 2

HCID 104886541-(4-Fluoro-2-methoxyphenyl)piperazineHCID 540590213-(3-chloropropyl)-6-methyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 702026803-{3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propyl}-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

Procedure

substituting 1-(4-fluoro-2-methoxyphenyl)piperazine and 3-(3-chloropropyl)-6-methyl-2,4(1H,3H)-pyrimidinedione gave 3-{3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propyl}-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 227°-229° C.; Anal.: Calcd. for C19H25FN4O3.(HCl)2 : C, 48.82; H, 6.20; N, 11.98%; Found: C, 48.72; H, 5.87; N, 11.72%;

Sources & evidence

ORD record
ord-991194a60d3044faae8a1c32d55907e0
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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