HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Fluoro-2-methoxyphenyl)piperazine → 3-{3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propyl}-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Fluoro-2-methoxyphenyl)piperazine | HCID 10488654 | — |
| Reactant | 3-(3-chloropropyl)-6-methyl-2,4(1H,3H)-pyrimidinedione | HCID 54059021 | — |
| Product | 3-{3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propyl}-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride | HCID 70202680 | — |
Reaction Steps
substituting 1-(4-fluoro-2-methoxyphenyl)piperazine and 3-(3-chloropropyl)-6-methyl-2,4(1H,3H)-pyrimidinedione gave 3-{3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propyl}-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 227°-229° C.; Anal.: Calcd. for C19H25FN4O3.(HCl)2 : C, 48.82; H, 6.20; N, 11.98%; Found: C, 48.72; H, 5.87; N, 11.72%;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05859014 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-991194a60d3044faae8a1c32d55907e0 |
| Source note | uspto-grants-1999_01 |