1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → HCID 70202243, compound

HRID 342585Notes

Reaction equation

HRID 342585 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[Cl:19][CH2:20][CH2:21][CH2:22][N:23]1[CH:28]=[C:27]([CH3:29])[C:26](=[O:30])[N:25]([C:31]2[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=2)[C:24]1=[O:38]>>[ClH:19].[F:18][C:2]([F:1])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][N:14]([CH2:20][CH2:21][CH2:22][N:23]2[CH:28]=[C:27]([CH3:29])[C:26](=[O:30])[N:25]([C:31]3[CH:32]=[CH:33][C:34]([F:37])=[CH:35][CH:36]=3)[C:24]2=[O:38])[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 104915651-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazineHCID 53891804HCID 53891804, compound

Product 1

HCID 70202243HCID 70202243, compound

Procedure

substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 1-(3-chloropropyl)-3-(4-fluorophenyl)-5-methyl-2,4(1H,3H)-pyrimidinedione gave 1-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-3-(4-fluorophenyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 220°-222° C.; Anal.: Calcd. for C26H28F4N4O3.(HCl)2.(H2O)0.1 : C, 52.46; H, 5.11; N, 9.41%; Found: C, 52.21; H, 4.91; N, 9.26%;

Sources & evidence

ORD record
ord-aae64c3b0af44a24a67d027611db733c
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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