4-Methylbenzyl chloride → HCID 70198305, compound

HRID 342609Notes

Reaction equation

HRID 342609 reaction equation
[F:1][C:2]([F:30])([F:29])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][N:20]2[C:25](=[O:26])[C:24]([CH3:27])=[CH:23][NH:22][C:21]2=[O:28])[CH2:13][CH2:12]1.[CH3:31][C:32]1[CH:39]=[CH:38][C:35]([CH2:36][Cl:37])=[CH:34][CH:33]=1>>[ClH:37].[F:30][C:2]([F:29])([F:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][CH2:19][N:20]2[C:25](=[O:26])[C:24]([CH3:27])=[CH:23][N:22]([CH2:31][C:32]3[CH:39]=[CH:38][C:35]([CH3:36])=[CH:34][CH:33]=3)[C:21]2=[O:28])[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 77224-Methylbenzyl chlorideHCID 35670025-Methyl-3-[3-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione] hydrochloride

Product 1

HCID 70198305HCID 70198305, compound

Procedure

substituting 3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-methyl-2,4(1H,3H)-pyrimidinedione and 4-methylbenzyl chloride gave 3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-1-(4-methylbenzyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 141°-143° C.; Anal.: Calcd. for C28H33F3N4O3.(HCl)2 : C, 55.89; H, 5.99; N, 9.12%; Found: C, 56.18; H, 5.99; N, 9.31%.

Sources & evidence

ORD record
ord-cae26e3884ae48cdb02367b5f71adcd4
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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