反应详情

To a solution of 4-cyanobenzaldehyde (1.97 g, 15.0 mmol) in 50 mL of ethanol at room temperature was added sodium borohydride (0.57 g, 15.0 mmol). After 4 days, the solution was quenched with saturated ammonoum chloride solution, then poured into EtOAc, washed with sat, NaHCO3 soln. and brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide the product (1.82 g, 92% yield) as a white waxy solid which was sufficiently pure for use in the next step without further purification.

1. customthe solution was quenched with saturated ammonoum chloride solution
2. additionpoured into EtOAc
3. washwashed
4. dry with materialand brine, dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated in vacuo