HCID 22117351, compound → HCID 70197194, compound

HRID 342637Notes

Reaction equation

HRID 342637 reaction equation
[SH:1][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[N:3]=1.[ClH:11].[Cl:12][CH2:13][C:14]1[C:19]([O:20][CH3:21])=[C:18]([S:22][CH2:23][CH2:24][CH2:25][Cl:26])[CH:17]=[CH:16][N:15]=1>C(O)(C)C.O>[ClH:12].[ClH:11].[Cl:26][CH2:25][CH2:24][CH2:23][S:22][C:18]1[CH:17]=[CH:16][N:15]=[C:14]([CH2:13][S:1][C:2]2[NH:6][C:5]3[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=3[N:3]=2)[C:19]=1[O:20][CH3:21]

Participants

5

Reactant 2

HCID 22117351HCID 22117351, compoundHCID 178527775HCID 178527775, compound

Product 1

HCID 70197194HCID 70197194, compoundYield 67%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3776IsopropanolSolvent

Procedure

2-Mercapto-1 H-benzimidazole (10 g) and 2-chloromethyl-4-(3-chloropropylthio)-3-methoxypyridine hydrochloride (1 equivalent) are stirred at 80° C. for 5 h in 150 ml of isopropanol and 15 ml of water, the mixture is cooled, and precipitated solid is filtered off and recrystallized from isopropanol/water. The title compound is obtained as a light brown powder; m.p. 117°-119° C. (dec.); yield: 67% of theory.

Workup

  1. customprecipitated solid
  2. filtrationis filtered off
  3. customrecrystallized from isopropanol/water

Sources & evidence

ORD record
ord-a3ec0c91a79540b7b8e7a9539b406956
Source dataset
uspto-grants-1999_01
Patent number
US05859030

Reaction notes

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