Ammonia → 4-Acetylbenzenesulphonamide

HRID 342650Notes

Reaction equation

HRID 342650 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[NH3:14]>C(O)C>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:14])(=[O:12])=[O:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 2664184-Acetylbenzenesulfonyl chloride

Product 1

HCID 740654-Acetylbenzenesulphonamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

131 g of product of Example 3 are added portionwise to 1 l of ethanol saturated with ammonia. The reaction mixture is stirred at ambient temperature for 24 h, then concentrated and water is added thereto. The solid obtained is filtered, then washed with isopropanol and pentane.

Workup

  1. concentrationconcentrated
  2. additionwater is added
  3. customThe solid obtained
  4. filtrationis filtered
  5. washwashed with isopropanol and pentane

Sources & evidence

ORD record
ord-c6e9ade2c5f14ec1a34bc4390c80e5d0
Source dataset
uspto-grants-1999_01
Patent number
US05859036

Reaction notes

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