反应详情

Ethyl 4-hydroxybenzoate (16.6 g), geranyl bromide (23.9 g), and potassium carbonate (27.6 g) were refluxed in acetone (200 ml) with stirring for 1 hour . The reaction mixture, with water added thereto, was extracted with ethyl acetate. The extract was dried over sodium sulfate anhydride and then concentrated under a vacuum. To the residue dissolved in ethanol (150 ml) were added sodium hydroxide (3.90 g) and water(50 ml) and the mixture was refluxed with stirring for 1 hour. After being concentrated under a vacuum, the reaction mixture was acidified with hydrochloric acid and then extracted with ethyl acetate. The extract was dried over sodium sulfate anhydride and then was concentrated under a vacuum. The resulting solid was recrystallized from n-hexane/ethyl acetate mixed solution, thereby yielding 223 g of the aimed compound.

1. extractionwas extracted with ethyl acetate
2. dry with materialThe extract was dried over sodium sulfate anhydride
3. concentrationconcentrated under a vacuum
4. dissolutionTo the residue dissolved in ethanol (150 ml)
5. additionwere added sodium hydroxide (3.90 g) and water(50 ml)
6. temperaturethe mixture was refluxed
7. stirringwith stirring for 1 hour
8. concentrationAfter being concentrated under a vacuum
9. extractionextracted with ethyl acetate
10. dry with materialThe extract was dried over sodium sulfate anhydride
11. concentrationwas concentrated under a vacuum
12. customThe resulting solid was recrystallized from n-hexane/ethyl acetate mixed solution