反应详情

A solution of 8 g of the compound obtained in step B in 100 ml of 100° EtOH, 5 ml of water and 0.6 g of NaHCO3 is hydrogenated at atmospheric pressure and at RT. The catalyst is filtered off and the filtrate is evaporated under vacuum. The residue is extracted with DCM, the extract is washed with water and dried over MgSO4 and the solvent is evaporated off under vacuum to give 6 g of the expected product.

1. customis hydrogenated at atmospheric pressure and at RT
2. filtrationThe catalyst is filtered off
3. customthe filtrate is evaporated under vacuum
4. extractionThe residue is extracted with DCM
5. washthe extract is washed with water
6. dry with materialdried over MgSO4
7. customthe solvent is evaporated off under vacuum