反应详情

To a stirring solution of 4-[5-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester (Example 1E) (4.0 g, 7.22 mmole) in toluene (80 mL) was added dimethylformamide dimethyl acetal (4.0 mL) and the mixture heated to reflux for 18 hours. The reaction was cooled, concentrated in vacuo to a foam and chromatographed on silica using 5% acetone/methylene chloride to give upon concentration of the product containing fractions the title compound 2.78 g.

1. temperaturethe mixture heated
2. temperatureto reflux for 18 hours
3. temperatureThe reaction was cooled
4. concentrationconcentrated in vacuo to a foam
5. customchromatographed on silica using 5% acetone/methylene chloride
6. customto give upon concentration of the product