Trifluoroacetic acid → HCID 53639496, compound

HRID 342713Notes

Reaction equation

HRID 342713 reaction equation
CC1(C)O[CH:5]([N:7](C)[C:8](=[O:19])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][C:16](=[O:18])[CH3:17])[CH2:4][O:3]1.FC(F)(F)[C:24](O)=[O:25]>ClCCl>[OH:3][CH:4]([CH2:24][OH:25])[CH2:5][NH:7][C:8](=[O:19])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][C:16](=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70345089HCID 70345089, compound

Product 1

HCID 53639496HCID 53639496, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The solution from 2-acetoxybenzoic acid 2,2-dimethyl-[1,3]dioxolan-4-yl-methylamide (184 mg, 0.63 mmol) in dichloromethane (5 ml) is treated with trifluoroacetic acid (1 ml). After 0.5 h at room temperature, the mixture is concentrated, the residue is taken up in toluene (10 ml) and the solution is concentrated. The residue is purified by column chromatography (dichloromethane/methanol=10/1). Yield: 132 mg.

Workup

  1. concentrationthe mixture is concentrated
  2. concentrationthe solution is concentrated
  3. customThe residue is purified by column chromatography (dichloromethane/methanol=10/1)

Sources & evidence

ORD record
ord-0992fa1bbfa2472a9ba620d5514d4d22
Source dataset
uspto-grants-1999_01
Patent number
US05859053

Reaction notes

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