12-Methoxydodecanoate → 12-Methoxydodecanoyl chloride

HRID 342721ノート

反応式

HRID 342721 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[CH3:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]CC(O)=O>C1(C)C=CC=CC=1>[CH3:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:1][C:2]([Cl:4])=[O:3]

参加物

4

反応物 2

HCID 142012-MethoxydodecanoateHCID 65578Oxalyl chloride

生成物 1

HCID 1961175912-Methoxydodecanoyl chloride収率 99.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Oxalyl chloride (16.0 g, 70 mmol) was added dropwise to a solution of 12-methoxydodecanoic acid (9.8 g, 77 mmol) in 300 mL of anhydrous toluene. After stirring at room temperature for 16 hours the solvent was removed on a rotary evaporator. The residue was taken up in anhydrous toluene and concentrated to give the title compound (17.4 g) as a yellow liquid. The structure was verified by infrared spectroscopy (1796 cm-1) and NMR.

後処理

  1. customwas removed on a rotary evaporator
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-826b2a5b37604c488655ae23e4757607
出典データセット
uspto-grants-1999_01
特許番号
US05859052

反応ノート

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