反应详情

A solution of 3-chloro-4-acetamidophenylacetic acid (180 grams, 0.79 moles) in methanol (2 L), was treated with concentrated HCl (200 mL) and the resulting solution refluxed for 6 hours and then stirred at room temperature for 16 hours. The mixture was concentrated in vacuo to about one-half its volume and ether (4 L) was added. The resulting precipitate was filtered, washed with ether and dried to give the title compound (173 grams) as a tan solid NMR, (CD3OD): δ3.70 (s, 2H); 3.73 (s, 3H); 7.35 (d, 1H); 7.43 (d, 1H); 7.56 (s, 1H).

1. temperaturethe resulting solution refluxed for 6 hours
2. concentrationThe mixture was concentrated in vacuo to about one-half its volume and ether (4 L)
3. additionwas added
4. filtrationThe resulting precipitate was filtered
5. washwashed with ether
6. customdried