反应详情

The product from step (e) (20 g) was added to a 1M solution of lithium aluminium hydride (1.5 molar equivalents) in THF and the mixture reflexed for 3 hours, then stirred for 16 hours at room temperature. The mixture was cooled to about 0° C., then quenched with water and 1N aqu. NaOH added. The resulting solid was broken up with additional water and the suspension heated at 50° C. for 5 minutes, then cooled to room temperature, diethyl ether (100 ml) added and filtered. The filtrate was evaporated in vacuo to give the desired product as an oil (82% yield).

1. temperatureThe mixture was cooled to about 0° C.
2. customquenched with water and 1N aqu
3. additionNaOH added
4. temperaturethe suspension heated at 50° C. for 5 minutes
5. temperaturecooled to room temperature
6. additiondiethyl ether (100 ml) added
7. filtrationfiltered
8. customThe filtrate was evaporated in vacuo