Water → HCID 54057436, compound

HRID 342964Notes

Reaction equation

HRID 342964 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[C:14]1[O:18][N:17]=[CH:16][CH:15]=1)([O-:3])=[O:2].[O-]CC.[Na+].O>C(O)C>[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:7]=[CH:6][C:5]=1[C:14](=[O:18])[CH2:15][C:16]#[N:17])([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 962WaterHCID 2723922Sodium ethoxideHCID 53802621HCID 53802621, compound

Product 1

HCID 54057436HCID 54057436, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of 5-(2-nitro-4-trifluoromethylphenyl)-isoxazole (4.91 g) in ethanol (35 ml) was added dropwise to a solution of sodium ethoxide in ethanol (prepared from 0.6 g sodium in 25 ml ethanol). The mixture was stirred at room temperature for 3 hours, poured into water (150 ml) and acidified to pH 1. It was extracted with ether (2×75 ml) and the combined extracts were washed with water, dried (anhydrous sodium sulphate) and filtered. The filtrate was evaporated to dryness and the residue was triturated with petroleum spirit (bp 60°-80° C.) and filtered to give 3-(2-nitro-4-trifluoromethylphenyl)-3-oxopropionitrile (4.9 g) as an off-white solid mp 79.5°-80.5° C.

Workup

  1. extractionIt was extracted with ether (2×75 ml)
  2. washthe combined extracts were washed with water
  3. dry with materialdried (anhydrous sodium sulphate)
  4. filtrationfiltered
  5. customThe filtrate was evaporated to dryness
  6. customthe residue was triturated with petroleum spirit (bp 60°-80° C.)
  7. filtrationfiltered

Sources & evidence

ORD record
ord-f409074381f34bb8afe546e13ed476b2
Source dataset
uspto-grants-1999_01
Patent number
US05859283

Reaction notes

Loading…