反应详情

温度

40 °C

A mixture of 4-(N,N-dimethylsulphamoyl)-2-trifluoromethylbenzonitrile (2.78 g), sodium hydroxide (130 mg) and ethanol was heated to 40° C. Hydrogen peroxide (7 ml of 30% solution) was then added and the mixture heated at 40° C. for 3 hours. After cooling the mixture was poured into water and extracted with ethyl acetate. The organic phase was washed with water, dried (anhydrous magnesium sulphate) and filtered. The filtrate was evaporated to dryness and the residue recrystallised from ethyl acetate/toluene to give 4-(N,N-dimethylsulphamoyl)-2-trifluoromethylbenzamide (1.39 g) as a white solid, m.p. 149°-156° C.

1. temperaturethe mixture heated at 40° C. for 3 hours
2. temperatureAfter cooling the mixture
3. extractionextracted with ethyl acetate
4. washThe organic phase was washed with water
5. dry with materialdried (anhydrous magnesium sulphate)
6. filtrationfiltered
7. customThe filtrate was evaporated to dryness
8. customthe residue recrystallised from ethyl acetate/toluene