反应详情

To a solution of 4-(methylthio)phenylacetic acid (18.3 g, 0.100 mol) in methylene chloride (200 mL) was added 1,1'-carbonyldiimidazole (16.3 g, 0.100 mol) portionwise. The mixture was stirred at room temperature for 20 minutes, and N,O-dimethylhydroxylamine hydrochloride (9.8 g, 0.100 mol) was added. The reaction mixture was stirred overnight at room temperature, diluted with ether (500 mL) and washed successively with 1N hydrochloric acid, saturated aqueous sodium bicarbonate and brine. The organic layer was dried over magnesium sulfate, filtered and the filtrate was concentrated in vacuo to give 20.9 g of N-methoxy-N-methyl-4-(methylthio)-benzeneacetamide as a clear oil (93%).

1. stirringThe reaction mixture was stirred overnight at room temperature
2. washwashed successively with 1N hydrochloric acid, saturated aqueous sodium bicarbonate and brine
3. dry with materialThe organic layer was dried over magnesium sulfate
4. filtrationfiltered
5. concentrationthe filtrate was concentrated in vacuo