反应详情

100 mL toluene, 10 g 2-nitrobenzyl alcohol, and 11.4 g octyl isocyanate were placed in a 200-mL roundbottom flask, heated at reflux under nitrogen for 2 hours, and then cooled. The reaction solution was washed with water several times and the resulting toluene solution was then dried over sodium sulfate. The sodium sulfate was filtered off and the solvent was removed from the filtrate on a rotary evaporator. The resulting solid was recrystallized twice from hexane, yielding 12.5 g o-nitrobenzyl n-octylcarbamate as light yellow needle-like crystals.

1. temperatureheated
2. temperatureat reflux under nitrogen for 2 hours
3. temperaturecooled
4. washThe reaction solution was washed with water several times
5. dry with materialthe resulting toluene solution was then dried over sodium sulfate
6. filtrationThe sodium sulfate was filtered off
7. customthe solvent was removed from the filtrate on a rotary evaporator
8. customThe resulting solid was recrystallized twice from hexane