Methanesulfonamide → HCID 67703360, compound

HRID 343286Notes

Reaction equation

HRID 343286 reaction equation
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[C:27]([Cl:28])=[C:26]([O:29][CH:30]([F:32])[F:31])[N:25]([CH3:33])[N:24]=3)=[C:19]([F:34])[CH:18]=2)=[C:7]([CH:14]=1)[O:8][CH:9]([CH3:13])[C:10](Cl)=[O:11])[CH3:2].[CH3:35][S:36]([NH2:39])(=[O:38])=[O:37]>C(Cl)Cl>[CH3:35][S:36]([NH:39][C:10](=[O:11])[CH:9]([O:8][C:7]1[CH:14]=[C:3]([CH2:1][CH3:2])[CH:4]=[CH:5][C:6]=1[CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[C:27]([Cl:28])=[C:26]([O:29][CH:30]([F:31])[F:32])[N:25]([CH3:33])[N:24]=2)=[C:19]([F:34])[CH:18]=1)[CH3:13])(=[O:38])=[O:37]

Participants

4

Reactant 2

HCID 72879MethanesulfonamideHCID 88370664HCID 88370664, compound

Product 1

HCID 67703360HCID 67703360, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
120 °C

Procedure

A stirring mixture of 2.6 0 grams (0.0050 mole) of 2-[5-ethyl-2-[3-fluoro-4-(4-chloro-5-difluoromethoxy-1-methylpyrazol-3-yl)phenoxymethyl]phenoxy]propanoic acid chloride and 0.52 gram (0.0055 mole) of methylsulfonylamine is heated at about 120° C. for two hours. The reaction mixture is then cooled and dissolved in about 35 mL of methylene chloride. The solution is washed with water, dried with magnesium sulfate, and filtered. The filtrate is concentrated under reduced pressure, yielding the title compound.

Workup

  1. temperatureThe reaction mixture is then cooled
  2. washThe solution is washed with water
  3. dry with materialdried with magnesium sulfate
  4. filtrationfiltered
  5. concentrationThe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-523e80af75cf4972be3d1607e131b8f8
Source dataset
uspto-grants-1999_01
Patent number
US05861359

Reaction notes

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