Phosphorus oxychloride → HCID 54002462, compound

HRID 343290Notes

Reaction equation

HRID 343290 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:13](=O)[N:12]=[C:11]([CH3:15])[N:10]=2)=[CH:5][CH:4]=1.P(Cl)(Cl)([Cl:18])=O>>[Cl:18][C:13]1[NH:12][C:11]([CH3:15])=[N:10][C:9]=1[C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 57217469HCID 57217469, compound

Product 1

HCID 54002462HCID 54002462, compound

Procedure

A stirred solution of 10.0 grams (0.049 mole) of 4-(4-methoxyphenyl)-2-methyl-imidazol-5-one in 50 mL of phosphorous oxychloride is heated at reflux for about three hours. After this time, the reaction mixture is concentrated under reduced pressure, yielding 5-chloro-4-(4-methoxyphenyl)-2-methylimidazole.

Workup

  1. temperatureat reflux for about three hours
  2. concentrationAfter this time, the reaction mixture is concentrated under reduced pressure

Sources & evidence

ORD record
ord-18224d0ddf644d30913b961644da0277
Source dataset
uspto-grants-1999_01
Patent number
US05861359

Reaction notes

Loading…