Hydrochloric Acid → N-[(1,2,3,4-tetrahydroacridin-9-yl)aminocarbonylmethyl]-L-alanine

HRID 343345Notes

Reaction equation

HRID 343345 reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:28])[C@H:7]([CH3:27])[NH:8][CH2:9][C:10]([NH:12][C:13]1[C:14]2[C:19]([N:20]=[C:21]3[C:26]=1[CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:11])C.Cl>>[CH2:25]1[C:26]2[C:21](=[N:20][C:19]3[C:14]([C:13]=2[NH:12][C:10]([CH2:9][NH:8][C@H:7]([C:6]([OH:28])=[O:5])[CH3:27])=[O:11])=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:22][CH2:23][CH2:24]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15839267HCID 15839267, compound

Product 1

HCID 54527659N-[(1,2,3,4-tetrahydroacridin-9-yl)aminocarbonylmethyl]-L-alanineYield 77.1%

Procedure

Into 12 ml of 1N aqueous solution of sodium hydroxide, was added 2 g of the compound obtained in Example 38 at room temperature, and the reaction was continued for 2 hours. To the reaction mixture, was added 15 ml of 1N hydrochloric acid at a temperature not higher than 15° C. to precipitate white crystals. The crystals were collected by filtration, washed with water and dried to obtain 1.42 g of the titled compound having the melting point of 238° to 242° C. (decomposed).

Workup

  1. customto precipitate white crystals
  2. filtrationThe crystals were collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-69357e908b8c41f589c13f5f7858a7b8
Source dataset
uspto-grants-1999_01
Patent number
US05861411

Reaction notes

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