HCID 53674931, compound → HCID 628623, compound

HRID 343355Notes

Reaction equation

HRID 343355 reaction equation
[CH3:1][N:2]1[C:11](=[O:12])[C:10]2[N:9]([CH3:13])[C:8]([CH:14]=[CH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-])=O)[CH:17]=3)=[N:7][C:6]=2[N:5]([CH3:25])[C:3]1=[O:4]>CN(C=O)C.[H][H].[Pd]>[CH3:1][N:2]1[C:11](=[O:12])[C:10]2[N:9]([CH3:13])[C:8]([CH2:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([NH2:22])[CH:17]=3)=[N:7][C:6]=2[N:5]([CH3:25])[C:3]1=[O:4]

Participants

4

Reactant 1

HCID 53674931HCID 53674931, compound

Product 1

HCID 628623HCID 628623, compound

Reagents, catalysts & solvents 2

HCID 178506449HCID 178506449, compoundCatalystHCID 6228DimethylformamideSolvent

Procedure

Compound 54 was made from 21b with H2 /Pd 50 psi in DMF for 3 h. mp 158°-160° C. 1H NMR DMSO-d6 d 2.82 (t, 2H J=8 Hz); 2.96 (t, 2H J=8 Hz); 3.20 (s, 3H N--CH3); 3.42 (s, 3H N--CH3); 3.69 (s, 3H N7 --CH3); 4.95 (s, 2H --NH2); 6.34-6.39 (3H, H-2 H-4 H-6); 6.90 (t, 1H J=8 Hz, H-5). MS (CI/NH3) m/e 314 (MH+).

Sources & evidence

ORD record
ord-5a9bd6796b3e4835831c0aa9ad3345bb
Source dataset
uspto-grants-1999_01
Patent number
US05861405

Reaction notes

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