2-Amino-5-bromo-3-methoxypyrazine → HCID 18704806, compound

HRID 343391Notes

Reaction equation

HRID 343391 reaction equation
[NH2:1][C:2]1[C:7]([O:8][CH3:9])=[N:6][C:5]([Br:10])=[CH:4][N:3]=1.[CH2:11]([O:18][C:19]([NH:21][C:22]1[CH:31]=[CH:30][CH:29]=[C:28]2[C:23]=1[CH:24]=[CH:25][CH:26]=[C:27]2[S:32](Cl)(=[O:34])=[O:33])=[O:20])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CO>[CH2:11]([O:18][C:19]([NH:21][C:22]1[CH:31]=[CH:30][CH:29]=[C:28]2[C:23]=1[CH:24]=[CH:25][CH:26]=[C:27]2[S:32]([NH:1][C:2]1[C:7]([O:8][CH3:9])=[N:6][C:5]([Br:10])=[CH:4][N:3]=1)(=[O:34])=[O:33])=[O:20])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 113447242-Amino-5-bromo-3-methoxypyrazineHCID 11463015HCID 11463015, compound

Product 1

HCID 18704806HCID 18704806, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The starting material 5-(N-benzyloxycarbonylamino)-N-(5-bromo-3-methoxy-2-pyrazinyl)-1-naphthalenesulphonamide was prepared using an analogous procedure to that described in Example 36, starting from proportionate amounts of 2-amino-5-bromo-3-methoxypyrazine and 5-(N-benzyloxycarbonylamino)-1-naphthalenesulphonyl chloride (obtained as described in Synlett., 1992, 661), in a yield of 11%; m.p. 226°-228° C.; mass spectrum (+ve FAB, methanol/NBA): 543 (H+H)+.

Sources & evidence

ORD record
ord-191977d039ab43238c88d2276ce60f70
Source dataset
uspto-grants-1999_01
Patent number
US05861401

Reaction notes

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