2-Amino-5-bromo-3-methoxypyrazine → HCID 18704806, compound

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Reaction Steps

The starting material 5-(N-benzyloxycarbonylamino)-N-(5-bromo-3-methoxy-2-pyrazinyl)-1-naphthalenesulphonamide was prepared using an analogous procedure to that described in Example 36, starting from proportionate amounts of 2-amino-5-bromo-3-methoxypyrazine and 5-(N-benzyloxycarbonylamino)-1-naphthalenesulphonyl chloride (obtained as described in Synlett., 1992, 661), in a yield of 11%; m.p. 226°-228° C.; mass spectrum (+ve FAB, methanol/NBA): 543 (H+H)+.

Provenance & Evidence