Trifluoroacetic acid → {4-[1-(3,4-Dichloro-benzyl)-6-(2-piperidin-4-yl-(E)-vinyl)-1H-indazol-3-yl]-piperidin-1-yl}-acetic acid trifluoroacetate

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Reaction Steps

4-{2-[3-(1-Tert-butoxycarbonylmethyl-piperidin-4-yl)-1-(3,4-dichloro-benzyl)-1H-indazol-6-yl]-(E)-vinyl}-piperidine-1-carboxylic acid tert-butyl ester (110 mg; 0.161 mmol) was stirred at 23° in trifluoroacetic acid (4 ml) under nitrogen for 5 h. The solvent was evaporated in vacuo and the residue triturated with dry ether to give the title compound as a white solid (90 mg; 74%).

Provenance & Evidence