Hydrochloric Acid → HCID 67594372, compound

Participants

Reaction Steps

A mixture of 4-{2-[3-(1-tert-butoxycarbonylmethyl-piperidin-4-yl)-1-(4-fluoro-benzyl)-1H-indazol-6-yl]-(E)-vinyl}-piperidine-1-carboxylic acid tert-butyl ester (400 mg, 0.63 mmol) in aqueous 5M hydrochloric acid (80 ml) was stirred at +23° under nitrogen for 4 h. The solution was evaporated in vacuo and the residue triturated with ether to give the title compound as a cream solid (299 mg).

Provenance & Evidence