Hydrochloric Acid → HCID 67594372, compound

HRID 343415Notes

Reaction equation

HRID 343415 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11](/[CH:14]=[CH:15]/[C:16]2[CH:24]=[C:23]3[C:19]([C:20]([CH:33]4[CH2:38][CH2:37][N:36]([CH2:39][C:40]([O:42]C(C)(C)C)=[O:41])[CH2:35][CH2:34]4)=[N:21][N:22]3[CH2:25][C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:47]>>[ClH:47].[F:32][C:29]1[CH:28]=[CH:27][C:26]([CH2:25][N:22]2[C:23]3[C:19](=[CH:18][CH:17]=[C:16](/[CH:15]=[CH:14]/[CH:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)[CH:24]=3)[C:20]([CH:33]3[CH2:38][CH2:37][N:36]([CH2:39][C:40]([OH:42])=[O:41])[CH2:35][CH2:34]3)=[N:21]2)=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67593435HCID 67593435, compound

Product 1

HCID 67594372HCID 67594372, compound

Procedure

A mixture of 4-{2-[3-(1-tert-butoxycarbonylmethyl-piperidin-4-yl)-1-(4-fluoro-benzyl)-1H-indazol-6-yl]-(E)-vinyl}-piperidine-1-carboxylic acid tert-butyl ester (400 mg, 0.63 mmol) in aqueous 5M hydrochloric acid (80 ml) was stirred at +23° under nitrogen for 4 h. The solution was evaporated in vacuo and the residue triturated with ether to give the title compound as a cream solid (299 mg).

Workup

  1. customThe solution was evaporated in vacuo
  2. customthe residue triturated with ether

Sources & evidence

ORD record
ord-159ccf68827d4fe3a0c3103612b98f9b
Source dataset
uspto-grants-1999_01
Patent number
US05861414

Reaction notes

Loading…