反应详情

温度

70 °C

A mixture of 3-bromo-5-chloro-2-hydroxypyridine (81 g), benzyl bromide (52 mL) and silver carbonate (97 g)in benzene (1 L) was heated at 70° C. for 1 h. The mixture was cooled to r.t. and then filtered through a bed of celite. The filtrate was concentrated and the residual off-white solid was recrystallized from hexane to provide the title compound as a white solid (102 g).

1. temperatureThe mixture was cooled to r.t.
2. filtrationfiltered through a bed of celite
3. concentrationThe filtrate was concentrated
4. customthe residual off-white solid was recrystallized from hexane