反应详情

温度

-5 °C

Combine 3-(3,4-dimethoxyphenyl)-3-(2-hydroxyethyl)pyrrolidine (2.27 g, 9.03 mmol) and N-methylmorpholine (2.48 mL, 22.6 mmol) in anhydrous dichloromethane (100 mL). Cool the reaction mixture to -5° C. with an salt-ice bath. Slowly, add 2-methoxy-5-(1H-tetrazol-1-yl)benzoyl chloride (9.5 mmol) as a solution in dichloromethane (30 mL). Warm to ambient temperature. After 18 hours, extract the reaction mixture with a saturated solution of potassium carbonate. Dry the organic layer over Na2SO4, filter, and concentrate invacuo to obtain the title compound.

1. temperatureWarm to ambient temperature
2. extractionextract the reaction mixture with a saturated solution of potassium carbonate
3. dry with materialDry the organic layer over Na2SO4
4. filtrationfilter
5. concentrationconcentrate invacuo