HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 343521Generated: October 29, 2026
Hydrochloric Acid → (+)-3-Phenyl-3-(2-hydroxyethyl)pyrrolidine hydrochloric acid salt
https://huagongshe.com/reaction/343521
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Tert-butyl 3-(2-hydroxyethyl)-3-phenylpyrrolidine-1-carboxylate | HCID 18465021 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (+)-3-Phenyl-3-(2-hydroxyethyl)pyrrolidine hydrochloric acid salt | HCID 18464563 | — |
Reaction Steps
Combine 1-t-butoxycarbonyl-3-phenyl-3-(2-hydroxyethyl)pyrrolidine (13.0 g, 44.6 mmol) and a solution of hydrochloric acid in dioxane (22.3 mL, 4M, 89.2 mmol). Heat to 50° C. After 1 hour, cool and add diethyl ether to give a solid. Collect the solid by filtration to give, after drying, the title compound: mp; 161°-163° C. [α]2D0 =+11.8 (c=0.563, methanol). Elemental Analysis calculated for C12H17NO·HCl: C 63.29; H 7.97; N 6.15; Found: C 63.21; H 7.86; N 6.05.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05861417 |
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| Source dataset | uspto-grants-1999_01 |
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| ORD ID | ord-d47becafdd4f4ae684e3cc5d9d2599c9 |
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| Source note | uspto-grants-1999_01 |
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