反应详情

温度

50 °C

Combine 1-t-butoxycarbonyl-3-phenyl-3-(2-hydroxyethyl)pyrrolidine (13.0 g, 44.6 mmol) and a solution of hydrochloric acid in dioxane (22.3 mL, 4M, 89.2 mmol). Heat to 50° C. After 1 hour, cool and add diethyl ether to give a solid. Collect the solid by filtration to give, after drying, the title compound: mp; 161°-163° C. [α]2D0 =+11.8 (c=0.563, methanol). Elemental Analysis calculated for C12H17NO·HCl: C 63.29; H 7.97; N 6.15; Found: C 63.21; H 7.86; N 6.05.

1. temperaturecool
2. customto give a solid
3. customCollect the solid
4. filtrationby filtration
5. customto give
6. customafter drying