Methanol → 4-(Pyrid-3-yl)piperidine-4-carboxylic acid amide hydriodic acid salt

Participants

Reaction Steps

Combine 4-(pyrid-3-yl)-piperidine-4-carboxylic acid amide (3.0 g, 14.6 mmol), methanol (:30 mL), and water (10 mL). Cool in an ice bath and add an aqueous solution of hydriodic acid (4.2 mL, 57%, 31.2 mmol). After 30 minutes, filter and evaporate the filtrate in vacuo to give a residue. Triturate the residue with methanol to give a solid. Collect the solid and dry in vacuo at 56° C. to give the title compound.

Provenance & Evidence