Methanol → 4-(Pyrid-3-yl)piperidine-4-carboxylic acid amide hydriodic acid salt

HRID 343532Notes

Reaction equation

HRID 343532 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([C:13]([NH2:15])=[O:14])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:2]=1.CO.[IH:18]>O>[IH:18].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([C:13]([NH2:15])=[O:14])[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[CH:2]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 24841Hydrogen iodideHCID 543724704-(Pyrid-3-yl)-piperidine-4-carboxylic acid amide

Product 1

HCID 867536174-(Pyrid-3-yl)piperidine-4-carboxylic acid amide hydriodic acid salt

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Combine 4-(pyrid-3-yl)-piperidine-4-carboxylic acid amide (3.0 g, 14.6 mmol), methanol (:30 mL), and water (10 mL). Cool in an ice bath and add an aqueous solution of hydriodic acid (4.2 mL, 57%, 31.2 mmol). After 30 minutes, filter and evaporate the filtrate in vacuo to give a residue. Triturate the residue with methanol to give a solid. Collect the solid and dry in vacuo at 56° C. to give the title compound.

Workup

  1. temperatureCool in an ice bath
  2. filtrationfilter
  3. customevaporate the filtrate in vacuo
  4. customto give a residue
  5. customTriturate the residue with methanol
  6. customto give a solid
  7. customCollect the solid
  8. customdry in vacuo at 56° C.

Sources & evidence

ORD record
ord-6e3a6b856cc84a8d913e0d4ac6c6b303
Source dataset
uspto-grants-1999_01
Patent number
US05861417

Reaction notes

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