反应详情

Combine 4-(pyrid-3-yl)-piperidine-4-carboxylic acid amide (3.0 g, 14.6 mmol), methanol (:30 mL), and water (10 mL). Cool in an ice bath and add an aqueous solution of hydriodic acid (4.2 mL, 57%, 31.2 mmol). After 30 minutes, filter and evaporate the filtrate in vacuo to give a residue. Triturate the residue with methanol to give a solid. Collect the solid and dry in vacuo at 56° C. to give the title compound.

1. temperatureCool in an ice bath
2. filtrationfilter
3. customevaporate the filtrate in vacuo
4. customto give a residue
5. customTriturate the residue with methanol
6. customto give a solid
7. customCollect the solid
8. customdry in vacuo at 56° C.