Hydrazine hydrate (1:1) → HCID 10858518, compound
Reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@@:9]1([CH2:12][N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)[CH2:11][O:10]1.O.[NH2:19][NH2:20]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:10])([CH2:12][N:13]1[CH:17]=[N:16][CH:15]=[N:14]1)[CH2:11][NH:19][NH2:20]Participants
3
Procedure
A process according to claim 1 which comprises reacting (R)-1-[2-(2,4-difluorophenyl)oxiran-2-ylmethyl]-1H-1,2,4-triazole with hydrazine hydrate to form 2-(2,4-difluorophenyl)-1-hydrazino-3-(1H-1,2,4-triazol-1-yl)propan-2-ol, reacting this product with methyl (E)-4-(2,2,3,3)-tetrafluoropropoxy)cinnamimidate, and subsequently reacting the (E)-N-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(2,2,3,3-tetrafluoropropoxy)cinnamamidrazone product with ethyl orthoformate to form (R)-2-(2,4-difluorophenyl)-1-(3-[(E)-4-(2,2,3,3-tetrafluoropropoxy)styryl]-1H-1,2,4-triazol-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol.
Sources & evidence
- ORD record
- ord-e887e558fc0b44fa902c9602c97b80c5
- Source dataset
- uspto-grants-1999_01
- Patent number
- US05861516
Reaction notes
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