Triethylamine → HCID 85701474, compound

HRID 343599Notes

Reaction equation

HRID 343599 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]=[C:11]=[S:12])([CH3:3])[CH3:2].Cl.C([O:16][C:17](=O)[CH2:18][NH:19][CH3:20])C.C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH3:20][N:19]1[CH2:18][C:17](=[O:16])[N:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:1]([CH3:3])[CH3:2])[C:11]1=[S:12]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1420522-Isopropylphenyl isothiocyanateHCID 171173Ethyl N-methylaminoacetate hydrochloride

Product 1

HCID 85701474HCID 85701474, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared by the procedure described in Example 1 using 14.2 g of 2-isopropylphenyl-isothiocyanate, 12.29 g of sarcosine ethyl ester hydrochloride, 16.0 g of triethyl amine, and 200 mL of chloroform. Crystallization from diethyl ether afforded the title compound (15.9 g) as a peach solid, m.p. 129°-131° C. Anal. Calcd. for C13H16N2OS: C, 62.87; H, 6.49; N, 11.28. Found: C, 62.89; H, 6.38; N, 11.28. Mass spectrum (EI, M.+) m/z 248.

Workup

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from diethyl ether

Sources & evidence

ORD record
ord-43543df7e75748109bc2f8686f9d24b1
Source dataset
uspto-grants-1999_01
Patent number
US05861517

Reaction notes

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