Hydrochloric Acid → HCID 67562114, compound

HRID 343672Notes

Reaction equation

HRID 343672 reaction equation
[N:1]1([C:7]([NH2:9])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:10][C:11]1[CH:12]=[C:13]([C:18]2([CH2:37][CH2:38][N:39]3[CH2:44][CH2:43][C:42]([C:48]4[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=4)([C:45]([OH:47])=[O:46])[CH2:41][CH2:40]3)[CH2:22][CH2:21][N:20]([C:23](=[O:36])[C:24]3[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32][CH3:33])=[C:26]([O:34][CH3:35])[CH:25]=3)[CH2:19]2)[CH:14]=[CH:15][C:16]=1[Cl:17].Cl>ClCCl>[ClH:10].[N:1]1([C:7]([NH2:9])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:10][C:11]1[CH:12]=[C:13]([C:18]2([CH2:37][CH2:38][N:39]3[CH2:44][CH2:43][C:42]([C:48]4[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=4)([C:45]([OH:47])=[O:46])[CH2:41][CH2:40]3)[CH2:22][CH2:21][N:20]([C:23](=[O:36])[C:24]3[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32][CH3:33])=[C:26]([O:34][CH3:35])[CH:25]=3)[CH2:19]2)[CH:14]=[CH:15][C:16]=1[Cl:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67648306HCID 67648306, compound

Product 1

HCID 67562114HCID 67562114, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepare by the method of example 66.4 using 1-[2-[3-(3,4-dichloro-phenyl)-1(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid morpholine-amide (2.34 g, 3.3 mmol) and dichloromethane saturated with hydrochloric acid (100 mL) to give the title compound: Rf =0.58 (silica gel, 10% methanol/dichloromethane).

Sources & evidence

ORD record
ord-ca138690521544d8ba0f873ff4176e9e
Source dataset
uspto-grants-1999_01
Patent number
US05861416

Reaction notes

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