反应详情

Combine 2-[3-(4-trifluoromethyl-phenyl)-1-(3-isopropoxy-benzoyl)-pyrrolidin -3-yl]-ethyl-bromide (8 mmol), 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (12 mmol), K2CO3 (36 mmol), KI (0.8 mmol), and THF/H2O (3/1, 80 mL). Heat at reflux for 72 h. Concentrate in vacuo to remove THF and extract with dichloromethane (2×50 mL). Extract the combined organic layers using water (50 mL). Dry over MgSO4, filter, and concentrate in vacuo to obtain a residue. Chromatograph on silica gel to obtain the title compound.

1. temperatureHeat
2. temperatureat reflux for 72 h
3. concentrationConcentrate in vacuo
4. customto remove THF
5. extractionextract with dichloromethane (2×50 mL)
6. extractionExtract the combined organic layers
7. dry with materialDry over MgSO4
8. filtrationfilter
9. concentrationconcentrate in vacuo
10. customto obtain a residue