反应详情

90.6 g (0.6 mol) of 6-methylanthranilic acid are added to a solution of 24.8 g (0.62 mol) of NaOH in 500 ml of water and 63.4 g (0.62 mol) of acetic anhydride are then added dropwise. After stirring for one hour, the mixture is acidified to pH 3 with conc. HCl with cooling, and the precipitate which deposits is filtered off with suction, washed with water and dried under reduced pressure at 50° C. Yield: 107 g (0.55 mol)=92% of theory, m.p.: 189°-190° C.

1. additionare then added dropwise
2. temperaturewith cooling
3. filtrationthe precipitate which deposits is filtered off with suction
4. washwashed with water
5. customdried under reduced pressure at 50° C