反应详情

4-Hydroxy-6-methyl-2-(methylthio)pyrimidine (9.20 g, 59 mmol) and phosphorous oxychloride (60 mL) were combined and refluxed for 3 hours. The reaction mixture was cooled to room temperature and poured onto crushed ice. The resultant aqueous mixture was extracted with ethyl acetate; and the organic layer washed with saturated aqueous sodium bicarbonate followed by a water wash, dried over magnesium sulfate, and dried in vacuo to give 4-chloro-6-methyl-2-(methylthio)pyrimidine (8.27 g, 80%), m.p. 37°-38° C.

1. temperaturerefluxed for 3 hours
2. additionpoured
3. customonto crushed ice
4. extractionThe resultant aqueous mixture was extracted with ethyl acetate
5. washand the organic layer washed with saturated aqueous sodium bicarbonate
6. washwash
7. dry with materialdried over magnesium sulfate
8. customdried in vacuo