HuagongsheHuagongshe Chemistry Print Report · For research reference only
(+/-)-5-(2,5-Dioxo-4-imidazolidinylmethyl)-3-(1-methyl-4-piperidyl)-1H-indole → (+/-)-3-[3-(1-Methyl-4-piperidyl)-1H-indol-5-yl]alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (+/-)-5-(2,5-Dioxo-4-imidazolidinylmethyl)-3-(1-methyl-4-piperidyl)-1H-indole | HCID 15233277 | — |
| Reactant | Barium hydroxide, monohydrate | HCID 17749100 | — |
| Solvent | Water | HCID 962 | — |
| Product | (+/-)-3-[3-(1-Methyl-4-piperidyl)-1H-indol-5-yl]alanine | HCID 22852202 | — |
Reaction Steps
A solution of the product from step (d) (2.4 g) and barium hydroxide hydrate (8.4 g) in water (50 ml) was refluxed for 72 hours, then cooled and evaporated in vacuo. The residue was taken up in hot methanol and filtered to remove barium salts.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05863935 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-318bfde53829421087aea779f67bc012 |
| Source note | uspto-grants-1999_01 |