Oxalyl chloride → HCID 10176594, compound

HRID 343983Notes

Reaction equation

HRID 343983 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].C(C[N:11]1[CH:19]=[C:17]([CH3:18])[C:15](=[O:16])[NH:14][C:12]1=[O:13])(O)=O>ClCCl>[Cl:4][C:2]([CH2:1][N:11]1[CH:19]=[C:17]([CH3:18])[C:15](=[O:16])[NH:14][C:12]1=[O:13])=[O:3]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 8537532-(5-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetic acid

Product 1

HCID 10176594HCID 10176594, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Oxalyl chloride (6.3 g, 50 mmol) is added dropwise over 5 minutes to a solution of 1-(carboxymethyl)thymine (9.2 g, 50 mmol) dissolved in dichloromethane (200 mL). The reaction is stirred until gas evolution has ceased and then for an additional 2 hours. The reaction mixture is evaporated to an oil.

Workup

  1. customThe reaction mixture is evaporated to an oil

Sources & evidence

ORD record
ord-7b10470b290f4568bb3f581f92e434fb
Source dataset
uspto-grants-1999_01
Patent number
US05864010

Reaction notes

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