Nitrogen → HCID 22494465, compound

HRID 344011Notes

Reaction equation

HRID 344011 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[OH-:9].[K+].N#N.F[C:14]1[CH:28]=[CH:27][C:17]([C:18]([C:20]2[CH:25]=[CH:24][C:23](F)=[CH:22][CH:21]=2)=[O:19])=[CH:16][CH:15]=1>CS(C)=O.C1C=CC=CC=1.CO>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[O:8][C:14]1[CH:28]=[CH:27][C:17]([C:18]([C:20]2[CH:25]=[CH:24][C:23]([O:9][C:6]3[CH:5]=[CH:4][CH:3]=[C:2]([Br:1])[CH:7]=3)=[CH:22][CH:21]=2)=[O:19])=[CH:16][CH:15]=1

Participants

8

Reactant 4

HCID 947NitrogenHCID 95824,4'-DifluorobenzophenoneHCID 115633-BromophenolHCID 14797Potassium Hydroxide

Product 1

HCID 22494465HCID 22494465, compoundYield 72%

Reagents, catalysts & solvents 3

HCID 241BenzeneSolventHCID 679Dimethyl SulfoxideSolventHCID 887MethanolSolvent

Procedure

A reaction mixture was prepared with 3.8g (22 mmol) of m-bromophenol, 20 ml of methanol, and 20 ml of benzene. To this reaction mixture, 20 ml of 1 N KOH was added while N2 gas was passed into the mixture, and the methanol and water were removed at a temperature of 100° C. or below. To the resultant, 20 ml of benzene was added and benzene was distilled off at a temperature of 100° C. or below. Subsequently, 2.18 g (10 mmol) of 4,4'-difluorobenzophenone and 30 ml of dimethylsulfoxide (DMSO) was added and reacted at 140° C. for 4 hours to obtain 3.8 g of 4,4'-bis(3-bromophenoxy) benzophenone. The yield was approximately 72%. The following is the reaction formula of this synthesis. ##STR7##

Workup

  1. customthe methanol and water were removed at a temperature of 100° C. or below
  2. additionTo the resultant, 20 ml of benzene was added
  3. distillationbenzene was distilled off at a temperature of 100° C. or below
  4. customreacted at 140° C. for 4 hours

Sources & evidence

ORD record
ord-79697ab8e0d549de9983b559376ad671
Source dataset
uspto-grants-1999_01
Patent number
US05864050

Reaction notes

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